Grant ID | RR210080 |
Awarded On | August 18, 2021 |
Title | Recruitment of First-Time, Tenure-Track Faculty Members |
Program | CPRIT Scholar |
Award Mechanism | Recruitment of First-Time, Tenure-Track Faculty Members |
Institution/Organization | Texas A&M Engineering Experiment Station |
Principal Investigator/Program Director | Jason George |
Cancer Sites | Leukemia, Lymphoma |
Contracted Amount | $1,999,309 |
Summary of Goals and Objectives |
Objective: The rationale for the proposed research is the need to better understand the extent to which cancer populations adopt active immune evasion strategies to evade T cell recognition in the setting of allogeneic CD8+ T cell immunotherapy. We currently lack a theoretical framework for cancer T cell evasion. Therefore, the objective of this research is to develop a mathematical model to quantify the degree to which cancer populations employ adaptive, immune-specific evasion strategies, to apply this model to experimental data detailing cancer immune recognition and evasion, and to propose model-predicted, optimized hematopoietic stem cell transplant (HSCT) strategies in the setting of a... |