Anthony M. Mustoe, Ph.D.
Baylor College of Medicine
|Grant ID: RR190054|
Recruitment of First-Time, Tenure-Track Faculty Members
University of North Carolina, Chapel Hill
May 15, 2019
RNA—the intermediary between the genetic code of DNA and proteins—is dysregulated in nearly every type of cancer, and this dysregulation can lead to disease even without any apparent underlying genetic mutations.
Understanding the regulatory role RNA plays in cancer may lead to new types of therapies, according to Anthony Mustoe, a researcher at Baylor College of Medicine in the Therapeutic Innovation Center (THINC) and the departments of Biochemistry and Molecular Biology, and Molecular and Human Genetics. Mustoe was recruited to Baylor in 2019 with the help of a First-Time Tenure-Track Award from CPRIT, from the University of North Carolina, Chapel Hill, department of Chemistry, where he was a postdoctoral fellow.
“Because RNA is an intermediate or ‘messenger’, it has often been cast as sort of an inconsequential player in driving biology and disease,” Mustoe says. “But our lab is really interested in RNA because it plays a key role in regulating gene and ultimately protein expression. To make an analogy to an email, RNA contains the header information about where the email gets sent. You don’t want an email to your friend to go to your boss, or a thousand copies of an email to show up in one person’s inbox.”