John Paul Shen, M.D.
The University of Texas MD Anderson Cancer Center
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|Grant ID: RR180035|
Recruitment of First-Time, Tenure-Track Faculty Members
University of California, San Diego
May 16, 2018
Modern genomic sequencing techniques reveal that cancers come with a bewildering variety of mutations. Cancers that have the same driving mutation but grow in different environments — skin vs. colon, for example — may respond completely differently to the same therapy.
Conversely, tumors growing in different patients in the same organ may superficially appear similar but are often genetically diverse. With little information about how a tumor will respond to treatment except trial and error, it is challenging for oncologists to identify the optimal therapy for each patient.