Margarida Albuquerque Almeida Santos, Ph.D.
Margarida Albuquerque Almeida Santos, Ph.D.
The University of Texas M.D. Anderson Cancer Center
Titles & Positions

  • Assistant Professor, Epigenetics and Molecular Carcinogenesis, Division of Basic Science

Institutional & Related Links

Profile

Biography

Grant Information

Grant ID: RR150039
Grant Mechanism: 
Recruitment of First-Time, Tenure-Track Faculty Members
Recruited From: 
National Cancer Institute/National Institutes of Health
Date Awarded: 
April 20, 2015
Grant Amount: 
$2,000,000

As a graduate student in the University of Lisbon Medical School, I participated in research that provided the first evidence for the differential effects of Notch in human lymphoid differentiation. This work led to my traveling to the United States during my final year of graduate school to collaborate with Dr. Warren Pear, a leader in Notch signaling, at the University of Pennsylvania.

After that, during my postdoctoral training with Dr. Andre Nussenzweig at NCI, I focused on chromatin modifications in the DNA damage response during class switch recombination and, more recently, on the role of DNA damage response proteins and epigenetic regulators in normal and malignant hematopoietic stem cells (HSCs).

This last work lead to the discovery of an unexpected tumor-promoting role of genome guardians in enforcing the oncogene-induced differentiation blockade in AML and was published in 2014 in Nature.

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