|Grant ID: RR150039|
Recruitment of First-Time, Tenure-Track Faculty Members
National Cancer Institute/National Institutes of Health
April 20, 2015
As a graduate student in the University of Lisbon Medical School, I participated in research that provided the first evidence for the differential effects of Notch in human lymphoid differentiation. This work led to my traveling to the United States during my final year of graduate school to collaborate with Dr. Warren Pear, a leader in Notch signaling, at the University of Pennsylvania.
After that, during my postdoctoral training with Dr. Andre Nussenzweig at NCI, I focused on chromatin modifications in the DNA damage response during class switch recombination and, more recently, on the role of DNA damage response proteins and epigenetic regulators in normal and malignant hematopoietic stem cells (HSCs).
This last work lead to the discovery of an unexpected tumor-promoting role of genome guardians in enforcing the oncogene-induced differentiation blockade in AML and was published in 2014 in Nature.