|Grant ID: RR150089|
Recruitment of First-Time, Tenure-Track Faculty Members
University of California, Berkeley
September 10, 2015
At every step in my scientific journey, I have studied how conserved fundamental processes within the cell can quickly and easily be uncovered in simple model organisms and applied to conditions of biomedical relevance.
As a graduate student with Dr. Douglas Cyr at UNC Chapel Hill, I investigated the toxic assembly of disease-causing amyloidogenic proteins in the budding yeast. From these studies, I discovered novel mechanisms of chaperone-mediated protein folding and spatial quality control, which have since been translated into the mammalian brain and are now targets of intervention against neurodegeneration.