Raghu Kalluri, M.D., Ph.D.
The University of Texas M.D. Anderson Cancer Center
|Grant ID: R1227|
Recruitment of Established Investigators
Harvard Medical School
August 02, 2012
Cells in the human body send messages back and forth to each other constantly, via nanoparticle-sized packets called exosomes. These messengers travel in and out of cells and throughout the bloodstream, carrying bits of genetic materials and proteins from one place to another, like a postal delivery service.
Now scientists have found a way to hitchhike on the postal truck, by enclosing a cancer drug inside an exosome envelope.
Exosomes bypass the body’s immune system, and help scientists solve the problem of how to get cancer drugs inside of cancer cells. Once inside, like a mail bomb, they shut down a cancer cell’s inner machinery.