Ronald Parchem Ph.D.
Baylor College of Medicine
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|Grant ID: RR150106|
Recruitment of First-Time, Tenure-Track Faculty Members
University of California, San Francisco
September 10, 2015
Dr. Ronald Parchem is a stem cell and developmental biologist studying the biology of cancer stem cells and metastasis. His research focuses on how cancer stem cells co-opt pluripotency factors, including microRNAs, to survive and metastasize. Specifically, Dr. Parchem will determine how microRNA-302 (miR-302), an essential stem cell miRNA important for early neurodevelopment, regulates the formation and behavior of cancer stem cells in different types of cancer. This work is a direct extension of his post-doctoral work, which identified that miR-302 is required for neural tube closure and embryonic viability. Loss of miR-302 in mice demonstrated that miR-302 regulates the timing of neural stem cell differentiation during embryonic development.