|Awarded On||November 19, 2014|
|Title||Development of a novel K-Ras therapeutic|
|Award Mechanism||Bridging the Gap: Early Translational Research Awards|
|Institution/Organization||The University of Texas Health Science Center at Houston|
|Principal Investigator/Program Director||John F Hancock|
|Cancer Sites||Colorectal, Lung and Bronchus, Pancreas|
Ras proteins are small molecular switches located on the inside of the limiting cell membrane, called the plasma membrane. In the “ON” state, Ras proteins relay signals from outside of the cell to the cell nucleus that instruct the cell to grow and divide. Cancer cells acquire mutations that permanently lock Ras proteins in the “ON” state. These mutations therefore lead to unregulated cell division resulting the growth of a tumor. Ras mutations have been found in approximately 20% of all human tumors. The major clinical problem is with a form of Ras called K-Ras that is mutated in more than 90% of pancreatic cancers, 50% of colon cancers and approximately 25% of non-small cell lung cancers. ...