Grant ID DP150065
Awarded On November 19, 2014
Title Development of a novel K-Ras therapeutic
Program Academic Research
Award Mechanism Bridging the Gap: Early Translational Research Awards
Institution/Organization The University of Texas Health Science Center at Houston
Principal Investigator/Program Director John F Hancock
Cancer Sites Colorectal, Lung and Bronchus, Pancreas
Contracted Amount $1,511,840
Lay Summary

Ras proteins are small molecular switches located on the inside of the limiting cell membrane, called the plasma membrane. In the “ON” state, Ras proteins relay signals from outside of the cell to the cell nucleus that instruct the cell to grow and divide. Cancer cells acquire mutations that permanently lock Ras proteins in the “ON” state. These mutations therefore lead to unregulated cell division resulting the growth of a tumor. Ras mutations have been found in approximately 20% of all human tumors. The major clinical problem is with a form of Ras called K-Ras that is mutated in more than 90% of pancreatic cancers, 50% of colon cancers and approximately 25% of non-small cell lung cancers. ...

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