Grant ID DP190021
Awarded On February 21, 2019
Title Off the Shelf CAR-NKT Cells for Treatment of Solid and Hematological Malignancy
Program Product Development Research
Award Mechanism Texas Company Product Development Awards
Institution/Organization Cell Medica
Principal Investigator/Program Director Kurt Gunter
Cancer Sites Leukemia, Lymphoma
Contracted Amount $8,742,509*

*Pending contract negotiation

Lay Summary

Cell Medica’s novel approach uses healthy donor immune cells (off-the-shelf) modified to treat a variety of incurable tumors. Current CAR T cell products are “autologous,” where a patient’s own isolated T cells are modified by a “chimeric antigen receptor” targeting that patient’s cancer when administered to that patient.

While effective for some blood cancers (lymphoma/leukemia), these products have several issues. Patient response rates need improvement, even in lymphoma, and safety is problematic. Time needed to modify a sick patient’s cells (weeks) is too long even as some patients do not generate enough cells for treatment. Also, CAR T cells are less effective for solid tumors as the ...

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