|Awarded On||August 17, 2022|
|Title||Single Dose 186RNL for Leptomeningeal Metastases: Multicenter Phase 1/2a Study to Determine MTD/MFD, Safety & Efficacy, Leading to Pivotal Registrational Trial|
|Program||Product Development Research|
|Award Mechanism||Texas Company Product Development Awards|
|Institution/Organization||PLUS Therapeutics, Inc.|
|Principal Investigator/Program Director||Andrew Sims|
|Cancer Sites||Breast, Lung and Bronchus, Skin|
PLUS Therapeutics' Rhenium-186 NanoLiposome (186RNL) is a novel radiotherapeutic being developed to combat rare and difficult-to-treat cancers. Currently in clinical development for recurrent glioblastoma, 186RNL is safe and well-tolerated while delivering a radiation dose to the tumor that is up to 15 times higher than typically achievable with standard radiation therapy. PLUS now plans to develop 186RNL to treat leptomeningeal metastases (LM), a rare but typically fatal complication of advanced cancer affecting the fluid-lined structures surrounding the brain and spinal cord. LM affects over 110,000 people in the U.S. every year and, even with the best available care, is rapidly fatal with...