7 Hills Pharma is a Texas-based company developing novel therapies for cancer. Our drug, 7HP349, could benefit melanoma and other solid tumor patients resistant to immune checkpoint inhibitor (ICI) therapy. ICIs use the immune system to fight tumors, and have made rapid strides in treating melanoma, non-small cell lung, renal, bladder and other cancers. However, 43% of melanoma patients develop ICI drug resistance and are left with limited treatment options. 7HP349 addresses a primary cause of ICI resistance, the inability of T cells to infiltrate tumors, and has shown the ability in preclinical studies to reverse ICI drug resistance and reduce or eliminate tumors. This proposal aligns with ...

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7 Hills Pharma is a Texas-based company developing novel therapies for cancer. Our drug, 7HP349, could benefit melanoma and other solid tumor patients resistant to immune checkpoint inhibitor (ICI) therapy. ICIs use the immune system to fight tumors, and have made rapid strides in treating melanoma, non-small cell lung, renal, bladder and other cancers. However, 43% of melanoma patients develop ICI drug resistance and are left with limited treatment options. 7HP349 addresses a primary cause of ICI resistance, the inability of T cells to infiltrate tumors, and has shown the ability in preclinical studies to reverse ICI drug resistance and reduce or eliminate tumors. This proposal aligns with CPRIT's mission to bring accessible treatment options to cancer patients, in particular to those in Texas. We have Orphan Drug Designation, Fast Track status, and an active IND for this indication with the FDA and have completed a Phase I clinical trial to show that 7HP349 is safe and well tolerated in humans. CPRIT funds will enable a Phase Ia/IIb study to confirm drug safety and positive responses with 7HP349 in ICI-resistant melanoma patients with progressive disease. If successful, this study will represent a new treatment paradigm for ICI-resistant cancers. 7 Hills will expand operations in Houston, creating high-quality jobs in drug development and clinical operations. 7 Hills is committed to Texas and will ensure that CPRIT funds are spent in Texas, whenever possible.

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