| Grant ID | RP100484 |
| Awarded On | January 20, 2010 |
| Title | Human T lymphocytes with anti-viral and anti-leukemic specificity as protection against infection and relapse after stem cell and cord blood transplantation |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | Baylor College of Medicine |
| Principal Investigator/Program Director | Catherine M Bollard |
| Cancer Sites | Childhood and Adolescent, Leukemia |
| Contracted Amount | $1,128,885 |
| Lay Summary |
Patients with life-threatening leukemia (cancer of the blood), can be cured with a bone marrow transplant (BMT) from a related or unrelated donor or cord blood transplant (CBT). However, the main causes of death after BMT are viral infections and relapse of the leukemia. Among the most common life-threatening viral infections after BMT are Cytomegalovirus (CMV), Epstein Barr virus (EBV), and Adenovirus (AdV) with infection rates up to 80%. In addition, up to 40% of patients with high-risk acute lymphoblastic leukemia will relapse after BMT. In the laboratory, Drs Dotti and Bollard (co-Principal Investigators) have developed a novel method to generate special T-cells from the BMT donor cal... |