| Grant ID | RP110262 |
| Awarded On | October 29, 2010 |
| Title | Rationally designed magnetic nanoconstructs for the imaging and hyperthermia of tumor cells and neovasculature |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | The Methodist Hospital Research Institute |
| Principal Investigator/Program Director | Paolo Decuzzi |
| Cancer Sites | Brain and Other Nervous System |
| Contracted Amount | $1,499,996 |
| Lay Summary |
The prognosis of brain tumors stays poor primarily because of the low accessibility to the malignant vasculature and tissue, and of the resistance to most cancer cytotoxic agents of brain tumor cells. This proposal will develop nanoconstructs (nCs) for the magnetic resonance imaging and highly localized thermal ablation of brain tumors. The nanoconstructs will consist of porous discoidal silicon particles, with a diameter ranging between 500 and 1000 nm, especially designed to recognize and adhere to the brain tumor microvasculature. Superparamagnetic gadolinium-nanotubes (GNTs) and iron oxide nanoparticles (SPIOs) will be loaded into the nC pores, providing the magnetic capacity. Phage disp... |