|Awarded On||November 02, 2011|
|Title||Small molecule inhibitors of proteasome assembly: a new strategy for cancer therapy|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||George N DeMartino|
|Cancer Sites||All Sites|
Many cancers result from abnormal levels of proteins that control cell growth. Levels of proteins that control cell growth are determined in an important way by their rate of destruction, a process that is highly regulated in normal states but is altered in cancer and other diseases. The destruction of many cellular proteins is carried out by a large enzyme complex called the proteasome. The proteasome exists in multiple forms that consist of a common element called the 20S proteasome, and any one of at least six variable elements. Different proteasome forms likely have different cellular roles, but little is known about how cells determine relative proportions of proteasome forms or how the...