|Awarded On||November 02, 2011|
|Title||Targeting prostaglandin substrate availability in colon cancer: Characterization of a novel arachidonic acid-deficient mouse model|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Agrilife Research|
|Principal Investigator/Program Director||Robert S Chapkin|
It is now apparent that products of fat metabolism, i.e., prostaglandins, promote colon cancer development by enhancing intestinal cell growth, migration and invasion, while inhibiting cell death. Not surprisingly, most studies to date have targeted prostaglandin biosynthetic and degradation enzymes in an attempt to suppress the tumor promoting action of prostaglandins. However, due to safety concerns surrounding the use of pharmaceutical drugs designed to target the cell machinery that synthesizes these metabolites, it is important to identify new targets of this critical dysregulated pathway. In this proposal, we will determine the utility of antagonizing the precursor molecules that can ...