Grant ID RP120046
Awarded On November 02, 2011
Title Mining the oncogenome: Functional genomics approaches for screening mutation drivers of pancreatic ductal adenocarcinoma.
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Kenneth L Scott
Cancer Sites All Sites, Pancreas
Contracted Amount $803,179
Lay Summary

A major emphasis in cancer research is focused on identifying early cancer indicators, or biomarkers, and other genes directly responsible for causing tumors that may serve as targets for new cancer therapies. Large-scale efforts toward sequencing the DNA of tumors have uncovered the enormous complexity of cancer genomes. Using such knowledge in the clinic will require new strategies to assess the functional significance of individual DNA mutations in genes. Recently we developed a screening platform that permits the over-expression of large numbers of genes to assess their ability to promote cancer. This approach successfully identified multiple melanoma genes whose expression drives metast...

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