|Awarded On||November 02, 2011|
|Title||Mining the oncogenome: Functional genomics approaches for screening mutation drivers of pancreatic ductal adenocarcinoma.|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Kenneth L Scott|
|Cancer Sites||All Sites, Pancreas|
A major emphasis in cancer research is focused on identifying early cancer indicators, or biomarkers, and other genes directly responsible for causing tumors that may serve as targets for new cancer therapies. Large-scale efforts toward sequencing the DNA of tumors have uncovered the enormous complexity of cancer genomes. Using such knowledge in the clinic will require new strategies to assess the functional significance of individual DNA mutations in genes. Recently we developed a screening platform that permits the over-expression of large numbers of genes to assess their ability to promote cancer. This approach successfully identified multiple melanoma genes whose expression drives metast...