|Awarded On||November 02, 2011|
|Title||Protein Palmitoyltransferases as Novel Therapeutic Targets for Acquired Lung Cancer Vulnerabilities|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Sandra L Hofmann|
|Cancer Sites||Lung and Bronchus|
The overall goal of the proposed work is to identify new targets for lung cancer therapy. A recent successful approach to cancer therapy is to identify enzymes, such as kinases, that are activated in tumor cells and then to design drugs to inhibit them. Kinases transfer phosphate groups to proteins to regulate them. A new family of enzymes was recently discovered (the DHHC family) that transfers fatty acid groups to proteins to regulate them in a similar way. Some of these DHHC enzymes cause cells to form tumors when the cells are forced to express them, and some are mutated in cancer or present as fusion proteins so that they are over-expressed. In a genome-wide screen to identify protein...