Grant ID RP120214
Awarded On November 02, 2011
Title Clinical Translation of Therapeutic siRNA in Solid Malignancies
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Robert L Coleman
Cancer Sites All Sites, Ovary
Contracted Amount $1,379,098
Lay Summary

Ovarian cancer remains the deadliest of all gynecologic malignancies. More than 75% of women diagnosed with the disease have advanced stage, for which, the majority develop recurrence. Tragically, recurrent disease is rarely (<1%) cured despite surgical and pharmacological interventions (including biologically-targeted agents), which is driving the need for innovative and novel therapeutic approaches. RNA interference (RNAi) is a normal regulatory process by which individual cells control the functionality of genes by producing short RNA fragments (siRNA) which, when bound, can cause gene repression or degradation. We have developed a systemically deliverable siRNA therapeutic (Epharna™),...

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