Grant ID RP120217
Awarded On November 02, 2011
Title Role of IL-17 family cytokines in colon inflammation and cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Chen Dong
Cancer Sites Colorectal
Contracted Amount $1,285,789
Lay Summary

Colorectal cancer, the third most common malignancy worldwide, is greatly affecting the health in Texas state with 9000 cases diagnosed each year and approximately 3400 deaths. Chronic intestinal inflammation is a major risk factor in the development of colon cancer. However, the regulation of inflammation during colon development is poorly understood. We as well as other groups have recently identified IL-17-producing T helper (TH17) cells as a new lineage of T cells that mediate tissue inflammation. Targeting IL-17 has given promising results in clinical trials against autoinflammatory diseases. Interestingly, colorectal cancer patients with high expression of the TH17 genes have been show...

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