|Awarded On||November 02, 2011|
|Title||Role of IL-17 family cytokines in colon inflammation and cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Chen Dong|
Colorectal cancer, the third most common malignancy worldwide, is greatly affecting the health in Texas state with 9000 cases diagnosed each year and approximately 3400 deaths. Chronic intestinal inflammation is a major risk factor in the development of colon cancer. However, the regulation of inflammation during colon development is poorly understood. We as well as other groups have recently identified IL-17-producing T helper (TH17) cells as a new lineage of T cells that mediate tissue inflammation. Targeting IL-17 has given promising results in clinical trials against autoinflammatory diseases. Interestingly, colorectal cancer patients with high expression of the TH17 genes have been show...