Grant ID RP120241
Awarded On November 02, 2011
Title T-Cell Therapy After Hematopoietic Stem Cell Transplantation
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Laurence Cooper
Cancer Sites Leukemia, Lymphoma
Contracted Amount $1,359,672
Lay Summary

Patients with cancerous B cells (non-Hodgkin lymphoma, small lymphocytic lymphoma, follicular lymphoma, and mantle cell lymphoma) that have relapsed or are resistant to therapies are at high risk of death. To control disease progression, these patients undergo autologous hematopoietic stem-cell transplantation (HSCT) enabling high doses of chemotherapy to be administered with concomitant rescue of bone marrow function upon infusion of their peripheral blood-derived stem cells (hematopoietic stem cells, HSC). Despite this intensive therapy, patients with active disease at time of HSCT have a survival of less than 20% due to a relapse in tumor burden. We seek to improve the outcome by employin...

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