|Awarded On||November 02, 2011|
|Title||Functional and structural characterization of small chemical compounds that arrest glioma stem cell growth with high activity and specificity|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Luis F Parada|
|Cancer Sites||Brain and Other Nervous System|
Glioma is a type of tumor that develops in the brain, and glioblastoma multiforme (GBM) is the most common, aggressive, and malignant form of glioma. Patients with GBM have a dismal prognosis, and most patients die within 15 months of being diagnosed. The current treatment for these tumors – surgical removal when possible followed by radiation and chemotherapy - is, unfortunately, ineffective at blocking eventual tumor regrowth. The ultimate goal of this project is to identify novel drugs to treat these insidious tumors and prevent them from regrowing. We have generated a mouse model of GBM by creating mutations in genes that are frequently mutated in human GBM. 100% of these mice develop GB...