Grant ID RP120262
Awarded On November 02, 2011
Title Functional and structural characterization of small chemical compounds that arrest glioma stem cell growth with high activity and specificity
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Luis F Parada
Cancer Sites Brain and Other Nervous System
Contracted Amount $1,499,532
Lay Summary

Glioma is a type of tumor that develops in the brain, and glioblastoma multiforme (GBM) is the most common, aggressive, and malignant form of glioma. Patients with GBM have a dismal prognosis, and most patients die within 15 months of being diagnosed. The current treatment for these tumors – surgical removal when possible followed by radiation and chemotherapy - is, unfortunately, ineffective at blocking eventual tumor regrowth. The ultimate goal of this project is to identify novel drugs to treat these insidious tumors and prevent them from regrowing. We have generated a mouse model of GBM by creating mutations in genes that are frequently mutated in human GBM. 100% of these mice develop GB...

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