|Awarded On||November 02, 2011|
|Title||Chemoprevention of Colon Cancer by Targeting APC-deficient Cells for Apoptosis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Xiangwei Wu|
Cancer chemoprevention holds promise for overcoming difficulties associated with the treatment of late-stage cancers. However, a broad translation of chemoprevention to the clinic has yet to materialize. Current prevention approaches have predominantly tended toward modulating tumorigenic pathways rather than eliminating large number of premalignant cells. This tendency reflects the effort to minimize toxicity. However, the effectiveness of such modulative agents is generally low to moderate, and long-term and continuous treatment is often required to produce any significant preventive benefit. In turn, long-term continuous therapy frequently produces unanticipated adverse effects even with ...