|Awarded On||November 02, 2011|
|Title||Regulation of Cyclooxygenase-2 (COX-2) Gene Expression by Noncoding RNAs in Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Bethany A Janowski|
|Cancer Sites||Colorectal, Lung and Bronchus|
Cancer cells can change how much of an important protein is made, and make proteins that are not found in normal cells. Understanding how cancer cells can make too much of a protein that allows cancer cells to grow faster than normal cells is crucial for designing anti-cancer agents. Protein production is usually thought to be controlled by other proteins that bind to specific regions within a gene. In cancer cells, chemical changes can alter the gene to make too much or too little of proteins that control cell growth. Over the past few years RNA, another cellular molecule, has been shown to play an important role in controlling when genes make proteins. This proposal describes a new...