|Awarded On||November 02, 2011|
|Title||CBM complex-mediated signaling pathways as potential therapeutic targets for EGFR-induced cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Xin Lin|
|Cancer Sites||All Sites|
Mutations and over-expression of Epidermal Growth Factor Receptor (EGFR), a type receptor that controls cell growth, are associated with tumorigenesis of various cancers. This aberrant expression of EGFR is found to induction of a family of transcription factors, NF-kB, which controls cell proliferation, survival, and migration. In this proposal, we will determine the requirement of a protein complex in mediating EGFR-induced NF-kB activation and EGFR-induced tumorigenesis. Results from this study will provide molecular insights for new therapeutic approaches against various cancers.