Grant ID RP120316
Awarded On November 02, 2011
Title CBM complex-mediated signaling pathways as potential therapeutic targets for EGFR-induced cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Xin Lin
Cancer Sites All Sites
Contracted Amount $915,974
Lay Summary

Mutations and over-expression of Epidermal Growth Factor Receptor (EGFR), a type receptor that controls cell growth, are associated with tumorigenesis of various cancers. This aberrant expression of EGFR is found to induction of a family of transcription factors, NF-kB, which controls cell proliferation, survival, and migration. In this proposal, we will determine the requirement of a protein complex in mediating EGFR-induced NF-kB activation and EGFR-induced tumorigenesis. Results from this study will provide molecular insights for new therapeutic approaches against various cancers.