|Awarded On||November 02, 2011|
|Title||Simultaneous Vascular Targeting and Tumor Targeting of Cerebral Breast Cancer Metastases Using a T Cell Receptor Mimic Antibody|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Tech University Health Sciences Center|
|Principal Investigator/Program Director||Ulrich Bickel|
|Cancer Sites||Brain and Other Nervous System, Breast|
The proposed work will explore a novel concept for the treatment of brain metastases of breast cancer. Recently there has been some progress in the therapy of breast cancer due to availability of new drugs. However, brain metastases are a major threat for patients because they seem to occur now more frequently and current possibilities for treatment are very limited. Only about one in five patients is alive one year after a brain metastasis has been detected. One of the main problems is that the blood vessels in the brain do not allow passage of most anticancer drugs and therefore drug concentrations in brain tumors are too low to be effective. We have recently identified a new type of anti...