|Awarded On||November 02, 2011|
|Title||A Lentivirus-Mediated Dual Library, Dual Selection Approach for the Identification of Surface Biomarkers and Antibodies Specific to Cancer Cells|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University|
|Principal Investigator/Program Director||Zhilei Chen|
|Cancer Sites||All Sites, Colorectal|
Current efforts to rapidly diagnose and treat cancer are compounded by a scarcity of available molecular signatures distinguishing cancerous cells from normal cells. There is therefore an urgent need to identify both molecular signatures unique to cancer cells and agents capable of delivering therapeutic cargo specifically to the cancer cells. The goal of this proposal is to develop a novel in vitro selection approach for the simultaneous discovery of proteins specific to the surface of cancer cells and antibodies that recognize the newly identified cancer-specific proteins as antigens. Specifically, we have devised an evolutionary selection scheme in an in vitro tissue culture setting where...