Grant ID RP120429
Awarded On November 02, 2011
Title A Lentivirus-Mediated Dual Library, Dual Selection Approach for the Identification of Surface Biomarkers and Antibodies Specific to Cancer Cells
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization Texas A&M University
Principal Investigator/Program Director Zhilei Chen
Cancer Sites All Sites, Colorectal
Contracted Amount $200,000
Lay Summary

Current efforts to rapidly diagnose and treat cancer are compounded by a scarcity of available molecular signatures distinguishing cancerous cells from normal cells. There is therefore an urgent need to identify both molecular signatures unique to cancer cells and agents capable of delivering therapeutic cargo specifically to the cancer cells. The goal of this proposal is to develop a novel in vitro selection approach for the simultaneous discovery of proteins specific to the surface of cancer cells and antibodies that recognize the newly identified cancer-specific proteins as antigens. Specifically, we have devised an evolutionary selection scheme in an in vitro tissue culture setting where...

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