Grant ID RP120459
Awarded On November 02, 2011
Title Contribution of the BRIGHT transcription factor to autoimmune Diffuse Large B-cell Lymphoma
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Philip W Tucker
Cancer Sites Lymphoma
Contracted Amount $947,367
Lay Summary

Lymphoma is a cancer of white blood cells, or lymphocytes. The two major types of lymphoma are Hodgkin lymphoma and non-Hodgkin lymphoma. There are two types of lymphocytes, T cells and B cells. Diffuse Large B-Cell Lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in the world, constituting approximately 30% of newly diagnosed cases. There are several forms of DLBCL, and the worse form is called Activated B-Cell (ABC)-DLBCL. ABC-DLBCL is very aggressive, fast-growing, and can move outside the lymphoid system to form deadly tumors all over the body. Autoimmunity is a misdirected immune response that occurs when the immune system goes awry and attacks the body. Autoimmunity can ca...

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