|Awarded On||November 02, 2011|
|Title||Contribution of the BRIGHT transcription factor to autoimmune Diffuse Large B-cell Lymphoma|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Philip W Tucker|
Lymphoma is a cancer of white blood cells, or lymphocytes. The two major types of lymphoma are Hodgkin lymphoma and non-Hodgkin lymphoma. There are two types of lymphocytes, T cells and B cells. Diffuse Large B-Cell Lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in the world, constituting approximately 30% of newly diagnosed cases. There are several forms of DLBCL, and the worse form is called Activated B-Cell (ABC)-DLBCL. ABC-DLBCL is very aggressive, fast-growing, and can move outside the lymphoid system to form deadly tumors all over the body. Autoimmunity is a misdirected immune response that occurs when the immune system goes awry and attacks the body. Autoimmunity can ca...