Grant ID RP120777
Awarded On March 29, 2012
Title P4: Will Suppressing Mast Cell Function Improve Immunotherapy for Pancreatic Cancer?
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Stephen E Ullrich
Cancer Sites Sarcoma
Contracted Amount $778,431
Lay Summary

Therapy for pancreatic ductal adenocarcinoma (PDAC) have lagged behind advances for most other cancers. PDAC is resistant to most conventional cancer therapies, including immunotherapy. The resistance to immunotherapy is paradoxical. Tumor antigens are found on PDAC cells, and cancer reactive cytolytic T cells are found in the blood of pancreatic cancer patients. Obviously, the immune system can recognize antigen(s) on pancreatic cancer cells and can mount a response against them. But the dismal survival rates suggest that the immune system is not clearing the cancer in the patient. Current thinking suggests that tumor-induced immunosuppression is the reason, and countering immune suppressio...

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