Grant ID RP120867
Awarded On March 29, 2012
Title An NMR resource for enhancing the discovery of novel cancer therapeutics at the University of Texas Health Science Center at San Antonio
Program Academic Research
Award Mechanism Shared Instrumentation Awards
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Dimitri Ivanov
Cancer Sites All Sites
Contracted Amount $1,082,063
Lay Summary

Standard chemotherapeutic agents function by indiscriminately killing rapidly growing cells, which are both cancer cells and normal cells. In contrast, targeted therapies block molecules that act on the specific pathways and processes used by cancer cells to grow and divide - they are less toxic than chemotherapies and offer many benefits, including enhanced quality of life and improved safety. Unfortunately, the discovery of novel targeted therapies remains stubbornly slow. The goal of this proposal is to implement an innovative new structure-based approach for drug discovery, known as fragment-based drug discovery or FBDD. FBDD uses a spectroscopic technique called NMR to identify drug-lik...

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