|Awarded On||March 29, 2012|
|Title||An NMR resource for enhancing the discovery of novel cancer therapeutics at the University of Texas Health Science Center at San Antonio|
|Award Mechanism||Shared Instrumentation Awards|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Dimitri Ivanov|
|Cancer Sites||All Sites|
Standard chemotherapeutic agents function by indiscriminately killing rapidly growing cells, which are both cancer cells and normal cells. In contrast, targeted therapies block molecules that act on the specific pathways and processes used by cancer cells to grow and divide - they are less toxic than chemotherapies and offer many benefits, including enhanced quality of life and improved safety. Unfortunately, the discovery of novel targeted therapies remains stubbornly slow. The goal of this proposal is to implement an innovative new structure-based approach for drug discovery, known as fragment-based drug discovery or FBDD. FBDD uses a spectroscopic technique called NMR to identify drug-lik...