|Awarded On||December 05, 2012|
|Title||Genes and Pathways Cooperating with p53 in LFS Tumorigenesis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Ralf Krahe|
Identification of the tumor suppressor gene TP53 (p53) ushered in a new era in cancer research. This gene alone has shaped many of our fundamental concepts in cancer biology. TP53 is now recognized as the single most altered gene in human cancers, and its central role in cancer biology has stood the test of time. The p53 pathway is a complex network that regulates cell growth and death, but its role in tumorigenesis is complex and our understanding is incomplete. Li-Fraumeni Syndrome (LFS) is an inherited childhood cancer caused by mutations in TP53. It has become increasingly clear that while TP53 mutations predispose LFS patients, additional genetic and epigenetic alterations are necess...