Grant ID RP130054
Awarded On December 05, 2012
Title Genes and Pathways Cooperating with p53 in LFS Tumorigenesis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Ralf Krahe
Cancer Sites Bone
Contracted Amount $1,452,982
Lay Summary

Identification of the tumor suppressor gene TP53 (p53) ushered in a new era in cancer research. This gene alone has shaped many of our fundamental concepts in cancer biology. TP53 is now recognized as the single most altered gene in human cancers, and its central role in cancer biology has stood the test of time. The p53 pathway is a complex network that regulates cell growth and death, but its role in tumorigenesis is complex and our understanding is incomplete. Li-Fraumeni Syndrome (LFS) is an inherited childhood cancer caused by mutations in TP53. It has become increasingly clear that while TP53 mutations predispose LFS patients, additional genetic and epigenetic alterations are necess...

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