|Awarded On||December 05, 2012|
|Title||K-ras Spatiotemporal Dynamics: Novel Therapeutic Targets|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Health Science Center at Houston|
|Principal Investigator/Program Director||John F Hancock|
|Cancer Sites||Colorectal, Corpus and Uterus, NOS, Lung and Bronchus, Pancreas|
Ras is a protein that operates as a molecular switch, toggling between an active “on- state” and an inactive “off-state” in response to growth signals received by the cell. When Ras is in the “on-state” it activates a signaling network that instructs the cell to divide. Unfortunately 15-20% of all human tumors acquire mutations that lock the Ras switch in the “on-state”. Cells with a mutant Ras switch therefore receive a constant signal to undergo cell division, resulting in the outgrowth of a tumor. The major clinical problem is with a form of Ras called K-Ras that is mutated in >90% of pancreatic cancers, ~50% of colon cancer and ~25% of non-small cell lung cancer. We have known for over 2...