|Awarded On||December 05, 2012|
|Title||Personalized risk assessment for families with Li-Fraumeni Syndrome|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Wenyi Wang|
|Cancer Sites||Bone, Brain and Other Nervous System, Breast|
The Li-Fraumeni syndrome (LFS) involves an inherited mutation in the p53 tumor suppressor gene, which allows different types of tumors to develop relatively early in life. This syndrome can be confused with others, especially the hereditary breast and ovarian cancer syndrome, making it difficult to counsel in high-risk clinics. Our objective is to improve the identification and screening of families with early-onset cancer at multiple sites by providing physicians and genetic counselors with tools to comprehensively assess both an individual’s chance of carrying the p53 mutation before he/she is tested, and the risk projection that an individual with this mutation will develop specific forms...