|Awarded On||December 05, 2012|
|Title||Deep sequencing oncoviral evolvomes as a personalized cancer diagnostic tool|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Jeffrey E Barrick|
|Cancer Sites||Cervix Uteri|
Infections of human papillomavirus (HPV) cause 100% of cervical cancers, but most HPV-infected individuals never develop cancer. Even if a high-risk HPV strain is detected in an individual, their cancer prognosis is uncertain: more than 91% of HPV infections are cleared naturally by the immune system. HPV vaccines exist that can prevent infection and thus cervical cancer, but they are currently ineffective against HPV strains which cause 30% of cervical cancer. So, there is a continued need to better understand why some HPV infections ultimately lead to cervical cancer and others do not. Our overall goal is to identify new HPV genetic variants associated with cancer. We will develop a per...