Grant ID RP130219
Awarded On December 05, 2012
Title The cephalostatin/ritterazine antineoplastics; Synthesis, activity, and structural and mechanistic studies of novel cancer-selective chemotherapeutics
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas at Austin
Principal Investigator/Program Director Seongmin Lee
Cancer Sites All Sites
Contracted Amount $955,094
Lay Summary

The cephalostatins/ritterazines (CSTAT) are amazing anticancer agents: First, they are extremely efficacious in killing most cancer cells and among the most potent anticancer agents ever tested by the National Cancer Institute; Second, they destroy cancer cells through a mechanism that is completely different from those of any known anticancer drugs; Third, they are 10-20 fold more toxic to cancer cells than normal cells, thereby being promising cancer-selective chemotherapeutics; Lastly, they inhibit novel anticancer targets called oxysterol-binding proteins. Despite their enormous potential for being cancer-selective anticancer drugs, the development of CSTAT-based drugs has been very grea...

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