|Awarded On||December 05, 2012|
|Title||The cephalostatin/ritterazine antineoplastics; Synthesis, activity, and structural and mechanistic studies of novel cancer-selective chemotherapeutics|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Seongmin Lee|
|Cancer Sites||All Sites|
The cephalostatins/ritterazines (CSTAT) are amazing anticancer agents: First, they are extremely efficacious in killing most cancer cells and among the most potent anticancer agents ever tested by the National Cancer Institute; Second, they destroy cancer cells through a mechanism that is completely different from those of any known anticancer drugs; Third, they are 10-20 fold more toxic to cancer cells than normal cells, thereby being promising cancer-selective chemotherapeutics; Lastly, they inhibit novel anticancer targets called oxysterol-binding proteins. Despite their enormous potential for being cancer-selective anticancer drugs, the development of CSTAT-based drugs has been very grea...