Grant ID RP130258
Awarded On December 05, 2012
Title Tumor cell lytic peptoids that target exposed phosphatidylserine
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization University of Houston
Principal Investigator/Program Director Damith G Udugamasooriya
Cancer Sites Brain and Other Nervous System, Breast, Leukemia, Lung and Bronchus, Prostate
Contracted Amount $735,629.13
Award Transfer Information

Previous Organization: The University of Texas Southwestern Medical Center

Expended at Previous Organization: $39,985.87

Lay Summary

New drugs that target cancer cells specifically promise to revolutionize cancer medicine. Because they are cancer-specific, they spare the rest of the body from toxic side effects. However, scientists quickly realized that protein targets for those drugs are not found in every cancer type and no universal cancer specific protein targets are available. We believe we have identified a global marker of cancer. The lipid phosphatidylserine (PS) is universally present in the tumor microenvironment and absent from healthy normal tissues. To target PS specifically, we selected a peptide-like molecule, called a peptoid, from a large library. The dimeric version of the peptoid potently killed cancer...

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