Grant ID RP130266
Awarded On December 05, 2012
Title Rational Redox-Driven Non-Toxic Therapeutic Strategies For Pediatric Brain Cancers (Carson Leslie Award)
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Texas Tech University Health Sciences Center
Principal Investigator/Program Director Kalkunte S Srivenugopal
Cancer Sites Brain and Other Nervous System
Contracted Amount $777,268
Lay Summary

Each year, about 4,300 children are diagnosed with a brain tumor in the United States. Childhood brain cancers are deadly and rank as number two killer among pediatric patients. The last 20 years have seen some marked improvements in the survival of patients with mild medulloblastomas, however, the outlook for malignant gliomas, high risk medulloblastomas, and diffuse brainstem gliomas in children has changed very little. Every brain tumor patient goes through chemotherapy using alkylating agents. However, the treatment fails mainly because of 3 reasons. First, there is inadequate delivery of anticancer drugs to the tumor. Second, a DNA repair protein called MGMT which removes the DNA d...

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