|Awarded On||December 05, 2012|
|Title||The metabolic phenome of human lung cancer.|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Ralph J DeBerardinis|
|Cancer Sites||Lung and Bronchus|
Metabolism is the sum of processes by which cells produce energy and grow. Cancer cells must reprogram their metabolism to achieve rapid growth in aggressive tumors. Reversing these metabolic changes would limit tumor growth and provide the basis for an entirely new repertoire of chemotherapeutic agents. However, despite almost a century of research, our knowledge about cancer metabolism is limited to a small handful of pathways and has failed to produce an integrated view of how cancer-causing mutations reprogram metabolism in cancer patients. Using a previous CPRIT High Impact/High Risk Award, we developed sensitive and efficient methods to profile metabolism in cancer cells grown in cultu...