|Awarded On||December 05, 2012|
|Title||The mTOR-dependent nuclear transport in cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Dos Sarbassov|
|Cancer Sites||All Sites|
Accumulation of cellular mass is a fundamental biological process known as cell growth and its deregulation is common in human cancers. Nutrients control cell growth by determining a rate of anabolic processes in cells. In response to environmental cues, the nutrient-sensing mTOR (mammalian Target Of Rapamycin) pathway coordinates the balance between anabolic and catabolic cellular processes. The protein kinase mTOR is a central component of this essential and highly conserved pathway. Our study indicates that mTOR in association with the nuclear pore component regulates the nutrient-dependent nuclear import of ribosomal proteins. It is a novel function of mTOR and we believe that the...