Grant ID RP130276
Awarded On December 05, 2012
Title The mTOR-dependent nuclear transport in cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Dos Sarbassov
Cancer Sites All Sites
Contracted Amount $929,920
Lay Summary

Accumulation of cellular mass is a fundamental biological process known as cell growth and its deregulation is common in human cancers. Nutrients control cell growth by determining a rate of anabolic processes in cells. In response to environmental cues, the nutrient-sensing mTOR (mammalian Target Of Rapamycin) pathway coordinates the balance between anabolic and catabolic cellular processes. The protein kinase mTOR is a central component of this essential and highly conserved pathway. Our study indicates that mTOR in association with the nuclear pore component regulates the nutrient-dependent nuclear import of ribosomal proteins. It is a novel function of mTOR and we believe that the...

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