|Awarded On||December 05, 2012|
|Title||Inhibition of DNA polymerase theta (POLQ) for radiosensitization of breast cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Richard D Wood|
Radiation therapy is very effective in some phases of breast cancer therapy. For others, particularly triple-negative breast cancer, radiation is not currently effective. An drug that increases sensitivity to radiation in tumors would be most valuable. The purpose of this proposal is to explore and develop a new target for improved therapy of breast cancer. This target is DNA polymerase theta (POLQ), a protein first isolated and studied in our laboratory. The goals of the research outlined here are to test the principle that reduction of POLQ in breast cancer cells is beneficial for therapy with radiation and to set up and test an assay suitable for high-throughput screening. We have disc...