|Awarded On||December 05, 2012|
|Title||Protein Array and Analysis Core (PAAC)|
|Award Mechanism||Core Facility Support Awards|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Mark T Bedford|
|Cancer Sites||All Sites|
A protein is a chain of amino acids. During protein synthesis, 20 different amino acids can be incorporated into a protein, which then folds to form a structure that will dictate its function in cells. Once synthesized, a protein can undergo further chemical modification to alter its cellular function through a process called posttranslational modification (PTM). PTMs can either alter the structure of a protein or generate a docking site for a binding protein. We are particularly interested in identifying and characterizing protein interactions that are driven by PTMs. Processes that regulate PTMs in normal cells become deregulated in cancer cells through altered functions of the enzymes tha...