|Awarded On||December 05, 2012|
|Title||Requirement for Ascl1 in Gliomagenesis|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jane E Johnson|
|Cancer Sites||Brain and Other Nervous System|
Malignant gliomas in both the adult and pediatric populations are among the most aggressive and lethal of all solid tumors. Since current therapies are not sufficient to stop these tumors, new targeted therapies are needed. An emerging theme in cancer biology is that stem/progenitor cell populations are responsible for propagating tumor growth. The proposed studies will use a mouse model and human tumor tissue to investigate the role of a transcription regulatory protein, Ascl1, found normally in development of the nervous system but is found aberrantly in many brain tumors. The function of this factor and the pathways controlled by this factor will be determined in glioblastoma formation an...