|Awarded On||December 05, 2012|
|Title||Role of MicroRNA in Lung Cancer Risk & Clinical Outcome Prediction|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Xifeng Wu|
|Cancer Sites||Lung and Bronchus|
Smoking accounts for 90% of lung cancer cases, but only about 10-15% of heavy smokers develop lung cancer, suggesting individual genetic susceptibility. Identifying genetic predisposition loci to lung cancer will help predict a person’s risk of developing lung cancer. In this project, we will first identify inherited genetic susceptibility factor of lung cancer using two of the largest lung cancer studies with 6,000 cases and 6,000 healthy controls. We designed a three-stage study to screen and validate inherited genetic variations in microRNA pathway as susceptibility loci of lung cancer. MicroRNAs are a class of small non-coding RNAs that regulate gene expression and play important roles ...