|Awarded On||December 05, 2012|
|Title||Discovery and optimization of natural and artificial ligands regulating Hypoxia Inducible Factor|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Richard Bruick|
|Cancer Sites||All Sites|
Human cells must monitor and respond to changes in their environment to survive. Oxygen, critical for many cellular functions, is among the most important external signals. In humans, oxygen is detected by a protein called Hypoxia Inducible Factor (HIF), which cells use to control hundreds of genes as oxygen levels change. Normally, these genes give cells the ability to adapt and survive under stress conditions. Unfortunately, this same response is exploited by cancer cells that hijack HIF to enable their own survival and proliferation. Given that this aberrant HIF function contributes to the growth of tumors and the aggressive nature of cancers, drugs that inactivate HIF could provide ...