|Awarded On||December 05, 2012|
|Title||Blocking TNFR1 increases tumor radiosensitivity and ameliorates radiation-induced cognitive impairments|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Mostafa W Gaber|
|Cancer Sites||All Sites, Brain and Other Nervous System|
Brain tumors are the most common solid tumors in childhood and while different treatments achieve increased rates of survival in cases such as medulloblastoma in other brain tumors such as gliomas the survival rates are unacceptably low. Radiation therapy is one of the most successful treatments for brain tumors. However, brain radiotherapy elicits an acute and long-term inflammatory response, which is a hallmark of radiation toxicity. Further, radiation therapy for some tumors is associated with declines in intelligence on the order of 15 IQ points over 4 years. This irreversible change in cognitive functioning ultimately impacts educational and occupational success, and could be prevented...