Grant ID RP130573
Awarded On December 05, 2012
Title Blocking TNFR1 increases tumor radiosensitivity and ameliorates radiation-induced cognitive impairments
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Mostafa W Gaber
Cancer Sites All Sites, Brain and Other Nervous System
Contracted Amount $1,357,896
Lay Summary

Brain tumors are the most common solid tumors in childhood and while different treatments achieve increased rates of survival in cases such as medulloblastoma in other brain tumors such as gliomas the survival rates are unacceptably low. Radiation therapy is one of the most successful treatments for brain tumors. However, brain radiotherapy elicits an acute and long-term inflammatory response, which is a hallmark of radiation toxicity. Further, radiation therapy for some tumors is associated with declines in intelligence on the order of 15 IQ points over 4 years. This irreversible change in cognitive functioning ultimately impacts educational and occupational success, and could be prevented...

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