|Awarded On||December 05, 2012|
|Title||Single organelle analysis for metabolites in tumor cells using microfluidic devices coupled to direct Nanoextraction-Nanospray|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||University of North Texas|
|Principal Investigator/Program Director||Guido F Verbeck|
|Cancer Sites||All Sites, Colorectal|
Micromanipulation is an important and useful tool that is used to manipulate small particles and cellular materials. Currently micromanipulation is being used in the biological sciences to transfer single cells, isolating them for future studies and analysis, and is also being used to isolate specific bacterial cells from a culture and retrieve them for further study. Our development of nanomanipulation has higher spatial resolution than micromanipulation, so new advances in the biological sciences can be made, specifically to sub cellular analysis and isolation within a single healthy and tumor cell. Recent advances in Mass Spectrometry sensitivity and nano-scale manipulation have led...