Grant ID RP130603
Awarded On December 05, 2012
Title Evaluation of the role of the BAP1 tumor suppressor gene in renal cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director James Brugarolas
Cancer Sites Kidney and Renal Pelvis
Contracted Amount $1,205,451
Lay Summary

We have discovered that the gene BAP1 is inactivated in 15% of renal tumors. We found that tumors with BAP1 mutations tend not to have mutations in PBRM1. Mutations in BAP1 or PBRM1 were observed in 70% of all renal tumors. Interestingly, whereas BAP1 mutation was associated with aggressive features (high tumor grade), tumors with PBRM1 mutations exhibited milder features. These findings establish the foundation for a classification of kidney cancer that is based on mutated genes. Since mutated genes are ultimately responsible for the behavior of cancer cells, these findings have far-reaching implications. In fact, we observed that loss of BAP1 sensitizes tumor cells to radiation, a finding ...

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