|Awarded On||December 05, 2012|
|Title||Evaluation of the role of the BAP1 tumor suppressor gene in renal cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||James Brugarolas|
|Cancer Sites||Kidney and Renal Pelvis|
We have discovered that the gene BAP1 is inactivated in 15% of renal tumors. We found that tumors with BAP1 mutations tend not to have mutations in PBRM1. Mutations in BAP1 or PBRM1 were observed in 70% of all renal tumors. Interestingly, whereas BAP1 mutation was associated with aggressive features (high tumor grade), tumors with PBRM1 mutations exhibited milder features. These findings establish the foundation for a classification of kidney cancer that is based on mutated genes. Since mutated genes are ultimately responsible for the behavior of cancer cells, these findings have far-reaching implications. In fact, we observed that loss of BAP1 sensitizes tumor cells to radiation, a finding ...