|Awarded On||December 05, 2012|
|Title||Imaging cancer with radiofluorinated organoboron/biomolecule conjugates|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University|
|Principal Investigator/Program Director||Francois Gabbai|
|Cancer Sites||All Sites|
The overall goal of this project is the discovery of novel methods for the preparation of radiopharmaceuticals which will be used to image cancer by Positron Emission Tomography (PET) using the positron emitting fluorine isotope 18F as a radiotracer. The use of this isotope is attractive because it can be easily prepared by proton bombardment of [18O]-water. Despite these advantages, 18F undergoes a rapid nuclear decay, making its incorporation into cancer-imaging agents a race against time. As an added complication, irradiation of [18O]-water produces [18F]-fluoride ions whose reactivity is lowered by the aqueous nature of the media. Thus, to minimize deactivation of the radiotracer, the [1...