|Awarded On||December 05, 2012|
|Title||Role of Long Non-Coding RNAs in Breast Cancers: Identification, Characterization, and Determination of Molecular Functions|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||W. Lee Kraus|
A key hurdle in developing better treatments for breast cancers is a lack of understanding at the molecular level of what promotes the growth of breast cancer cells. We are interested in determining why some breast cancers respond estrogens, while others lose responsiveness and rely instead on growth factors. In this regard, we have developed a new method for detecting molecules in cells called “RNAs.” This has allowed us to identify and characterize a large set of previously unidentified RNAs, called long non-coding RNAs (lncRNAs), in human breast cancer cells. LncRNAs are known to be aberrantly produced in cancer cells, and they play a key role in promoting and maintaining cancer cell ...