Grant ID RP130624
Awarded On December 05, 2012
Title Diagnosis and Prognosis of Cancers through Glycomics and Glycoproteomics
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Texas Tech University
Principal Investigator/Program Director Yehia Mechref
Cancer Sites Breast
Contracted Amount $1,226,370
Lay Summary

Brain metastasis is a life-threatening condition for women with advanced metastatic breast cancer. Since current chemotherapeutic regimens lack efficacy in established brain metastatic lesions, new strategies allowing the reduction or eradication of the formation of brain metastases of breast cancer are needed. The development of any effective strategy is highly dependent on identifying the molecular structure and physical properties of metastatic breast cancer cells which able to extravasate through the blood-brain barrier (BBB). Aberrant glycosylation for decades has been recognized as the attribute of many mammalian diseases, including osteoarthritis, cystic fibrosis and cancer. This pr...

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