|Awarded On||December 05, 2012|
|Title||Diagnosis and Prognosis of Cancers through Glycomics and Glycoproteomics|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Texas Tech University|
|Principal Investigator/Program Director||Yehia Mechref|
Brain metastasis is a life-threatening condition for women with advanced metastatic breast cancer. Since current chemotherapeutic regimens lack efficacy in established brain metastatic lesions, new strategies allowing the reduction or eradication of the formation of brain metastases of breast cancer are needed. The development of any effective strategy is highly dependent on identifying the molecular structure and physical properties of metastatic breast cancer cells which able to extravasate through the blood-brain barrier (BBB). Aberrant glycosylation for decades has been recognized as the attribute of many mammalian diseases, including osteoarthritis, cystic fibrosis and cancer. This pr...