|Awarded On||August 20, 2014|
|Title||Role of DNA METHYLTRANSFERASE 3A in Hematologic Malignancies|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Margaret A Goodell|
|Cancer Sites||Breast, Leukemia, Lung and Bronchus, Lymphoma|
Cancers of the blood, including leukemias, lymphomas, and myelodysplastic syndrome (MDS), are increasingly common with age. Recent advances in identifying genetic changes that occur in these cancers have revealed a number of new genes whose mutation drives the formation of these aggressive diseases. A gene called DNMT3A has been found to be altered in 5% to 50% of many different types of blood cancers, making this an extremely important contributor to blood malignancies. The goal of this project is to use a mouse model we developed, which has lost DNMT3A, to study the function of this gene in blood cancers. In these mice, we have found many of the same types of cancer that occur in humans wi...